Understanding:
• Every individual has a unique proteome
The proteome is the totality of proteins expressed within a cell, tissue or organism at a certain time
- The proteome of any given individual will be unique, as protein expression patterns are determined by an individual’s genes
The proteome is always significantly larger than the number of genes in an individual due to a number of factors:
- Gene sequences may be alternatively spliced following transcription to generate multiple protein variants from a single gene
- Proteins may be modified (e.g. glycosylated, phosphorylated, etc.) following translation to promote further variations
Formation of the Proteome
