Essential Idea:
Metabolic reactions are regulated
in response to the cell’s needs
Understandings:
- Metabolic pathways consist of chains and cycles of enzyme-catalysed reactions
- Enzymes lower the activation energy of the chemical reactions that they catalyse
- Enzyme inhibitors can be competitive or non-competitive
- Metabolic pathways can be controlled by end-product inhibition
Applications:
- End-product inhibition of the pathway that converts threonine to isoleucine
- Use of databases to identify potential new anti-malarial drugs
Skills:
- Calculating and plotting rates of reaction from raw experimental results
- Distinguishing different types of inhibition from graphs at specified substrate concentration